Dissecting genetic and epigenetic networks that control sperm production
Germ cell-mediated transmission of epigenetic information
Development of non-hormonal male birth control pills
Discovered many cellular and molecular processes that control fundamental aspects of spermiogenesis, e.g., sperm connecting piece/neck formation, cytoplasmic removal, sperm transport from rete testis to epididymis, etc.
Defined the transcriptomes of various small RNA species in testis, ovary, spermatogenic cells and oocytes. Established the SpermBase, a database for sperm-borne small RNAs in various mammalian species.
Demonstrated that sperm-borne RNAs contribute to epigenetic inheritance and proposed novel ideas regarding the mechanisms of action of paternal/sperm or maternal/oocyte RNAs in epigenetic inheritance.
Reported endo-siRNAs in spermatogenic cells, in addition to ES cells and oocytes. Discovered mitochondrial genome-encoded small RNAs (mitosRNAs).
Defined an essential role of miRNA and/or endo-siRNA biogenesis in gametogenesis and normal GI physiology. Identified that two miRNA clusters, miR-449 and miR-34b/c, exclusively control multiciliogenesis.
We have identified spermdeformin 1 (SD-1) as an ideal drug candidate for reversible, non-hormonal male contraception.